Publications

"Observation of the protein-inorganic interface of ferritin by cryo-electron microscopy." Sen, S., Thaker, A., Williams, D., Chiu, P.-L., Nannenga, B.L. bioRxiv, 10.1101/2024.09.04.611303 (2024). 

"Upregulation of the proto-oncogene Src kinase in Alzheimer's disease: from molecular interactions to therapeutic potential." Mastroeni, D., Chan, C.K., Morshed, N., Diouf, D., de Ávila, C. Suazo, C., Nolz, J., Lopatin, U., Wang, Q., Serrano, G., Beach, T., Dunkley, T., Jensen, K., Van Den Hove, D., White, F.M., Chiu, P.-L., Singharoy, A., Reiman, E.M., and Readhead, B.P. bioRxiv, 10.1101/2024.02.07.579336 (2024). 

"Structure and dynamics of cholesterol-mediated aquaporin-0 arrays and implications for lipid rafts." *Chiu, P.-L., *Orjuela, J.D., de Groot, B.L., #Aponte-Santamaría, C., and #Walz, T. eLife, 10.7554/eLife.90851.3 (2024). 

"Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by a class of triazole inhibitors." *Nandi, P., *DeVore, K., *Wang, F., Li, S., Walker, J.D., Truong, T.T., LaPorte, M.G., Wipf, P., Schlager, H., McCleerey, J., Paquette, W., Columbres, R.C.A., Gang, T., Poh, Y.-P., Fromme, P., Flint, A.J., Wolf, M., Huryn, D.M., #Chou, T.-F., and #Chiu, P.-L. Commun Chem 7, 177 (2024). 

"Molecular mechanism of Rubisco activase: dynamic assembly and Rubisco remodeling." Waheeda, K., Kitchel, H., Wang, Q., and #Chiu, P.-L. Frontiers in Molecular Biosciences, 10 (2023). 

"Molecular asymmetry of photosynthetic supercomplex from green sulfur bacteria." Puskar, R., Truong, C.D., Swain, K., Chowdhury, S., Chan, K.-Y., Li, S., Cheng, K.-W., Wang, T.Y., Poh, Y.-P., Mazor, Y., Liu, H., Chou, T.-F., Nannenga, B.L., and #Chiu, P.-L. Nature Communications, 13, 5824 (2022). 

"Coarse-grained simulations for the characterization and optimization of hybrid protein-DNA nanostructures." *Narayanan, R.P., *Procyk, J., Nandi, P., Prasad, A., Xu, Y., Poppleton, E., Williams, D.R., Zhang, F., Yan, H., #Chiu, P.-L., #Stephanopoulos, N., and #Šulc, P. ACS Nano, 16, 14086-14096 (2022). 

"Probing structural perturbation of biomolecules by extracting cryo-EM data heterogeneity." DeVore, K. and Chiu, P.-L. Biomolecules, 12, 628 (2022). 

"ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome." Baker, A.T., Boyd, R.J., Sarkar, D., Crespo, A.T., Chan, C.K., Bates, E., Waraich, K., Vant, J., Wilson, E., Truong, C.D., Lipka-Lloyd, M., Fromme, P., Vermaas, J., Williams, D., Machiesky, K., Heurich, M., Nagalo, B.M., Coughlan, L., Umlauf, S., Chiu, P.-L., Rizkallah, P.J., Cohen, T.S., Parker, A.L., Singharoy, A., and Borad, M.J. Science Advance, 7, eabl8213 (2021). 

"Sample preparation using lipid monolayer method for electron crystallographic studies." Truong, C.D., Williams, D., Zhu, M., Wang, J.C.-H., and Chiu, P.-L. Journal of Visualized Experiments, 177, e63015 (2021). 

"Conserved L464 in p97 D1-D2 linker is critical for p97 cofactor regulated ATPase activity." *Zhang, X., *Gui, L., *Li, S., *Nandi, P., Wong, D.E., Moen, D.R., Lin, H.J., #Chiu, P.-L., and #Chou, T.-F. Biochemical Journal, 478, 3185-3204 (2021). 

"Structural and functional analysis of disease-linked p97 mutant complexes." Nandi, P., Li, S., Columbres, R.C.A., Wang, F., Williams, D.R., Poh, Y.-P., #Chou, T.-F., and #Chiu, P.-L. International Journal of Molecular Sciences, 22, 8079 (2021). 

"Cryo-EM reveals conformational flexibility in apo DNA polymerase zeta." Truong, C.D., Craig, T.A., Cui, G., Botuyan, M.V., Serkasevich, R.A., Chan, K.-Y., #Mer, G., #Chiu, P.-L., and #Kumar, R. Journal of Biological Chemistry, 297, 100912 (2021). 

"Protein secondary structure signatures from energy loss spectra recorded in the electron microscope." March, K., Venkatraman, K., Truong, C.D., Williams, D., Chiu, P.-L., and Rez, P. Journal of Microscopy, 282, 215-223 (2021). 

"Sample preparation and data collection for electron crystallographic studies on membrane protein structures and lipid-protein interaction." Chan, K.-Y., Truong, C.D., Poh, Y.-P., and Chiu, P.-L. Methods in Molecular Biology, 2215, 247-265 (2021). 

"Structural basis of redox modulation on chloroplast ATP synthase." Yang, J.-Y., Williams, D., Kandiah, E., #Fromme, P., and #Chiu, P.-L. Communications Biology, 3, 482 (2020). 

"A library of aminoglycoside-derived lipopolymer nanoparticles for delivery of small molecules and nucleic acids." Godeshala, S., Miryala, B., Dutta, S., Christensen, M.D., Nandi, P., Chiu, P.-L., and Rege, K. Journal of Materials Chemistry B, 8, 8558-8572 (2020). 

"Dynamic self-assembly of detonation nanodiamond in water." Chang, S.L.Y., Reineck, P., Williams, D., Bryant, G., Opletal, G., El-Demrdash, S.A., Chiu, P.-L., Ōsawa, E., Barnard, A.S., and Dwyer, C. Nanoscale, 12, 5363-5367 (2020). 

"Membrane directed expression in Escherichia coli of BBA57 and other virulence factors from the Lyme disease agent Borrelia burgdorfeni." Robertson, K.E., Truong, C.D., Craciunescu, F.M., Yang, J.-Y., Chiu, P.-L., Fromme, P., and Hansen, D.T. Scientific Reports, 9, 1-15 (2019). 

"The C. elegans 3'UTRome V2: an updated genomic resource to study 3'UTR biology. " Steber, H.S., Gallante, C., Chiu, P.-L., and Mangone, M. Genome Research, 29, 2104-2116 (2019). 

"The structure of the photosystem I IsiA super-complex. " Toporik, H., Li, J., Williams, D., Chiu, P.-L., and Mazor, Y. Nature Structural and Molecular Biology, 26, 443-449 (2019). 

"Macromolecular assemblies of the mammalian circadian clock." *Aryal, R.P., *Kwak, P.B., *Tamayo, A.G., Chiu, P.-L., Walz, T., and Weitz, C.J. Molecular Cell, 67, 770-782 (2017). 

"Electron crystallography reveals that substrate release from the PTS IIC glucose transporter is coupled to a subtle conformational change." *Kalbermatter, D., *Chiu, P.-L., Jeckelmann, J.-M., Ucurum, Z., Walz, T., and Fotiadis, D. Journal of Structural Biology, 199, 39-45 (2017). 

"The structural basis for the functional comparability of factor VIII and the long-acting variant rFVIIIFc." Leksa, N.C., Chiu, P.-L., Bou-Assaf, G.M., Quan, C., Liu, Z., Goodman, A.B., Chambers, M.G., Tsutakawa, S.E., Hammal, M., Peters, R.T., Walz, T., and Kulman, J.D. Journal of Thrombosis and Haemostasis, 15, 1167-1179 (2017). 

"Magnetically directed two-dimensional crystallization of OmpF membrane proteins in block copolymers. " Klara, S.S., Saboe, P.O., Sines, I.T., Babaei, M., Chiu, P.-L., DeZorzi, R., Dayal, K., Walz, T., Kumar, M., and Mauter, M.S. Journal of the American Chemical Society, 138, 28-31 (2016). 

"Evaluation of super-resolution performance of the K2 electron counting camera using 2D crystals of aquaporin-0. " *Chiu, P.-L., *Li, X., Li, Z., Beckett, B., Brilot, A.F., Grigorieff, N., Agard, D.A., Cheng, Y., and Walz, T. Journal of Structural Biology, 192, 163-173 (2015). 

"2D and 3D crystallization of the wild-type IIC domain of the glucose PTS transporter from Escherichia coli." Kalbermatter, D., Jeckelmann, J.-M., Chiu, P.-L., Ucurum, Z., Walz, T., and #Fotiadis, D. Journal of Structural Biology, 191, 376-380 (2015). 

"Mapping the interaction between factor VIII and von Willebrand factor by electron microscopy and mass spectrometry." *Chiu, P.-L., *Bou-Assaf, G., Chhabra, E.S., Chambers, M.G., Liu, L., Peters, R., #Kulman, J.D., and #Walz, T. Blood, 126, 935-938 (2015). 

"Effect of lipid head groups on double-layered two-dimensional crystals formed by aquaporin-0." *Hite, R.K., *Chiu, P.-L., Schuller, J., and #Walz, T. PLoS ONE, 10, e0117371 (2015). 

"Ligand-induced structural changes in the cyclic nucleotide-modulateed potassium channel MloK1." Kowal, J., Chami, M., Baumgartner, P., Arheit, M., Chiu, P.-L., Rangl, M., Scheuring, S., #Nimigean, C.M., and #Stahlberg, H. Nature Communications, 5, 3106-3115 (2014). 

"Nose-to-brain transport of aerosolized quantum dots following acute exposure." Hopkins, L.E., Patchin, E.S., Chiu, P.-L., Brandenberger, C., Smiley-Jewell, S., and #Pinkerton, K.E. Nanotoxicology, 8, 885-893 (2014). 

"Visualizing macromolecular complexes with in situ liquid scanning transmission electron microscopy." Evans, J.E., Jungjohann, K.L., Wong, P.C.K., Chiu, P.-L., Dutrow, G.H., Arslan, I., and #Browning, N.D. Micron, 43, 1085-1090 (2013). 

"The use of trehalose in the preparation of specimens for electron microscopy." Chiu, P.-L., Kelly, D.F., and #Walz, T. Micron, 42, 762-772 (2011). 

"An optical and microPET assessment of thermally-sensitive liposome biodistribution in the Met-1 tumor model: importance of formulation." Paoli, E.-E., Kruse, D.E., Seo, J.W., Zhang, H., Kheirolomoom, A., Watson, K.D., Chiu, P.-L., Stahlberg, H., and #Ferrara, K.W. Journal of Control Release, 143, 13-22 (2010).